Topical Sequential Therapy in Psoriasis

Topical sequential therapy is a widely practiced technique in the treatment of psoriasis that provides a balance between maximizing efficacy and minimizing side-effects.

Topical therapy is indicated for psoriasis patients whose affected body area is less than 10-20% of their skin, the mainstay being topical corticosteroids. However, long term side effects of topical cortico steroids limit their use in psoriasis. On the other hand, calcipotriene, a vitamin D3 derivative topical agent used in psoriasis is comparatively safe, but not as effective as steroids in controlling psoriasis. It has been shown that regimens in which patients apply both calcipotriene and super potent corticosteroids have demonstrated superiority over either agent used alone.

Topical Sequential Therapy in Psoriasis